Where Are Mhc Molecules Located on a Cell

CD4 and CD8 are expressed on the surface of T cells and they serve as TCR coreceptors by virtue of two properties. Second the cytoplasmic tails of both coreceptors.

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First the extracellular domains of these coreceptors bind MHC class II and I molecules respectively and thus participate in TCR recognition of MHC-bound peptide antigens by stabilizing T cellAPC interactions.

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